This article focuses on the sustainability of gendered agricultural income-generating activities in Sonora, near the Mexico/USA border, in the context of climate change. Farming, and fruit and vegetable home-processing enterprises, still predominate in the area. However, several types of fruits can no longer be produced in this area due to warmer temperatures. Climate change has implications for the sustainability of these activities, which will affect women and men differently, affecting control over their livelihoods and food security. The article makes recommendations for development policies and programmes, for these and similar agricultural communities worldwide.